Q-Andrew: a consolidated QOS management framework

Tese de mestrado em Segurança Informática, apresentada à Universidade de Lisboa, através da Faculdade de Ciências, 2008As redes IP convergentes são compostas por uma diversidade de tecnologias que suportam múltiplos tipos de serviços com diferentes características. Cada fabricante de equipamento activo de rede usa sistemas de manutenção proprietários, incompatíveis com equipamentos de outros fabricantes. Para um operador de telecomunicações a gestão da Qualidade de Serviço, numa rede composta por vários fabricantes, é uma tarefa complexa e dispendiosa. Algumas tarefas requerem configuração manual para garantir a compatibilidade entre configurações de equipamentos de fabricantes diferentes. Melhorar a resposta operacional e reduzir os custos de operação nestas circunstâncias é apenas possível com a consolidação da gestão de rede. Para responder a este desafio, propomos: Um conjunto de mecanismos geradores de configurações de Qualidade de Serviço, consistentes entre equipamentos de diversos fabricantes; A definição de um modelo abstracto de representação destas configurações, reutilizável em futuras aproximações de gestão consolidada de rede; Por fim, descrevemos uma aplicação de demonstração onde algumas das propostas apresentadas são concretizadas, tendo como objectivo futuro a sua utilização numa rede real de um operador de telecomunicações nacional, onde são utilizados equipamentos de diversos fabricantes.Converged IP networks consist of diverse technologies and support both legacy and emerging services. Different vendors use separate management systems to achieve similar goals. Manual provisioning today represents a large portion of the total effort required to manage a complex IP network. A consolidated Quality-of-Service policy is difficult to implement in heterogeneous networks. Creating and maintaining such policies is very demanding in terms of operations. For this reason, reducing operational costs while improving Quality-of-Service Management is only possible through a consolidated approach to network management. To leverage operations in converged IP networks, we propose the following: A mechanism to automatically generate consistent configurations across a network with equipment from different vendors; A framework definition such that network element configurations can be specified using a common model; Applying some of the methods proposed to an application that can be used in a real network with diverse technologies and equipment vendors

Perception of Portuguese Nurses

Funding: The present study was funded by the Center for Research, Innovation, and Development in Nursing, in Portugal, by means of grants provided to some of the authors.The COVID-19 pandemic brought many changes and challenges to health professionals, due to a lack of knowledge when dealing with the disease, fear of contagion, and the sequelae that characterize long COVID. To deal with this situation, respiratory rehabilitation programs are recommended in face-to-face and/or telerehabilitation modalities. (1) Background: This study had as its primary aim identifying the aspects/components to be considered in the planning and implementation of telerehabilitation interventions that guarantee transitional care for people with long COVID-19 after hospitalization and as a secondary aim identifying the positive aspects of telerehabilitation. (2) Methods: The method used to answer the research question was a focus group, carried out online with eight nurses specialized in rehabilitation nursing. The answers to the semi-structured interview were subjected to content analysis, and qualitative data analysis software (WebQDA®) was used to organize and analyze the findings. (3) Results: Four categories emerged from the content analysis: coordination between care levels; transitional care telerehabilitation intervention; advantages of telerehabilitation; and opportunities. (4) Conclusions: These findings make an important contribution to the reorganization of transitional care, allowing the identification of central aspects to be considered in the planning and implementation of telerehabilitation programs for people with long COVID.publishersversionpublishe

On the Relevance of Soft Tissue Sarcomas Metabolic Landscape Mapping

Soft tissue sarcomas (STS) prognosis is disappointing, with current treatment strategies being based on a "fit for all" principle and not taking distinct sarcoma subtypes specificities and genetic/metabolic differences into consideration. The paucity of precision therapies in STS reflects the shortage of studies that seek to decipher the sarcomagenesis mechanisms. There is an urge to improve STS diagnosis precision, refine STS classification criteria, and increase the capability of identifying STS prognostic biomarkers. Single-omics and multi-omics studies may play a key role on decodifying sarcomagenesis. Metabolomics provides a singular insight, either as a single-omics approach or as part of a multi-omics strategy, into the metabolic adaptations that support sarcomagenesis. Although STS metabolome is scarcely characterized, untargeted and targeted metabolomics approaches employing different data acquisition methods such as mass spectrometry (MS), MS imaging, and nuclear magnetic resonance (NMR) spectroscopy provided important information, warranting further studies. New chromatographic, MS, NMR-based, and flow cytometry-based methods will offer opportunities to therapeutically target metabolic pathways and to monitorize the response to such metabolic targeting therapies. Here we provide a comprehensive review of STS omics applications, comprising a detailed analysis of studies focused on the metabolic landscape of these tumors.publishe

Exercício físico na pessoa com demência: Revisão Sistemática de Literatura

Background: Dementia is characterized by a set of disorders that involving a progressive loss of cognitive functions as well as affecting the skill necessary for the normal development of activities of daily living. Objective: Identify the benefits of physical exercise at the cognitive, sensory and motor level in the person with dementia. Method: Systematic Review of literature, started with the question: "What are the benefits of physical exercise in people with dementia?". The research was carried out using the electronic database platforms: EBSCOHost and BVS, having been identified, selected, evaluated in a methodological quality and included articles that take into account the PRISMA recommendations. Results: There were included seven studies meeting the inclusion criteria, that is, primary experimental studies, addressing the practice of physical exercise in people with dementia and Alzheimer Disease, published in the last 5 years (2014-2018), in Portuguese, English and Spanish, were included, with full text of free access. Conclusions: This Systematic Review reveals evidence of the beneficial effects of physical exercise on cognition and motor ability in people with dementia.Introducción: La demencia es caracterizada por un conjunto de trastornos que engloban una pérdida progresiva de las funciones cognitivas y afecta la destreza que es necesaria para el desarrollo normal de las actividades de vida diaria. Objectivo: Identificar los beneficios de ejercicio físico a nivel cognitivo, sensorial y motor en la persona con demencia. Método: Revisión Sistemática de la Literatura con la cuestión de la investigación "¿Cuáles son los beneficios del ejercicio físico en las personas con demencia?". La investigación fue realizada con recurso a plataformas de bases de datos electrónicas EBSCOHost y Biblioteca Virtual en Salud, habiendo sido identificados, seleccionados, evaluados en la calidad metodológica e incluidos artículos de acuerdo con las recomendaciones del PRISMA. Resultados: Se incluyeron siete estudios que cumplieron los criterios de inclusión, es decir, estudios primarios experimentales que aborden el ejercicio físico en personas con demencia, publicado en los últimos cinco años (2014-2018), en portugués, Inglés y Español, con texto integral de libre acceso. Conclusiones: Esta revisión sistemática de la literatura revela evidencia de los efectos del ejercicio sobre cognición, agitación, depresión y capacidad motora en personas con demencia.Introdução: A demência é caraterizada por um conjunto de transtornos que englobam uma perda progressiva das funções cognitivas e afeta a destreza que é necessária ao desenvolvimento normal das atividades de vida diária. Objetivo: Identificar os benefícios do exercício físico a nível cognitivo, sensorial e motor na pessoa com demência. Método: revisão sistemática da literatura com a questão de pesquisa “Quais os benefícios do exercício físico em pessoas com demência?”. A pesquisa foi realizada com recurso a plataformas de bases de dados eletrónicas EBSCOHost e Biblioteca Virtual em Saúde, tendo sido identificados, selecionados, avaliados na qualidade metodológica e incluídos artigos de acordo com as recomendações do PRISMA. Resultados: Foram incluídos 7 estudos que cumpriam os critérios de inclusão, ou seja, estudos primários experimentais, que abordam a prática de exercício físico em pessoas com demência, publicados nos últimos 5 anos (2014-2018), em português, inglês e espanhol, com texto integral de livre acesso. Conclusões: Esta revisão sistemática de literatura revela evidência dos efeitos benéficos do exercício sobre cognição, agitação, depressão e capacidade motora em pessoas com demência

O cuidado transicional na pessoa após internamento por COVID-19

info:eu-repo/semantics/publishedVersio

Laurus nobilis (laurel) aqueous leaf extract's toxicological and anti-tumor activities in HPV16-transgenic mice

Cancers induced by human papillomavirus (HPV) infection remain a significant public health threat, fueling the study of new therapies. Laurel (Laurus nobilis) compounds and extracts recently showed in vitro activity against HPV-transformed cell lines. This work aims to evaluate the in vivo efficacy and hepatic toxicity of a laurel extract in a transgenic mouse model of HPV16-induced cancer. The extract was administered in drinking water (20 mg per animal per day) for three consecutive weeks, using four experimental groups (n = 10) (group I: HPV16−/− without treatment, group II: treated HPV16−/−, group III: HPV16+/− without treatment and group IV: treated HPV16+/−). Following the treatment period, animals were sacrificed and skin samples were used to classify skin lesions histologically. Toxicological parameters included hematological and biochemical blood markers, splenic and hepatic histology and hepatic oxidative stress. The extract did not prevent the progression of HPV16-induced cutaneous lesions in this model. The treated wildtype animals showed mild hepatitis, while transgenic animals suffered weight loss. However, there were no changes concerning hematological, biochemical and hepatic oxidative stress markers.This work was supported by: Integrative Research in Environment, Agro-Chains and Technology no. NORTE-01- 0145-FEDER-000017, in its line of research entitled ISAC, cofinanced by the European Regional Development Fund (ERDF) through NORTE 2020 (North Regional Operational Program 2014/2020). European Investment Funds by FEDER/COMPETE/ POCI– Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER-006958 and National Funds by FCT - Portuguese Foundation for Science and Technology, under the project UID/AGR/04033/2013. This study was also funded by Liga Portuguesa Contra o Cancro, by the Research Center of the Portuguese Institute of Oncology of Porto (CI-IPOP 37-2016), by project POCI-01-0145- FEDER-006939 (Laboratory for Process Engineering, Environment, Biotechnology and Energy – LEPABE), project POCI-01-0145-FEDER-006958 and UID/AGR/04033/2013, funded by FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) – and by national funds through FCT – Fundação para a Ciência e a Tecnologia; Rui M. Gil da Costa was funded by grant number SFRH/BPD/85462/2012 from FCT, funded by the Portuguese Government and the Social European Fund. The authors are also grateful to FCT, Portugal and FEDER under Programme PT2020 for financial support to CIMO (UID/AGR/ 00690/2013), and to the Interreg España-Portugal for financial support through the project 0377_Iberphenol_6_E.info:eu-repo/semantics/publishedVersio

HERA - Environmental Risk Assessment of a contaminated estuarine environment: a case study

Sado River estuary is located in the west coast of Portugal. Previous environmental studies identified industrial contamination, non-point anthropogenic sources and contamination coming from the river, all promoting accumulation of polluted sediments with known impacts on the ecological system. Surrounding human populations have intense economic fishery activities. Together with agriculture, estuary fishing products are available to local residents. Food usage previously characterized through ethnographic studies suggests exposure to estuarine products, farming products, and water in daily activities, as potential routes of contamination. It is well established that long term exposure to heavy metals are associated with renal and neurological diseases, most heavy metals are classified as carcinogenic and teratogenic.Instituição Financiadora: FCT; Instituições participantes: IMAR -Instituto do Mar (coord.)e PRÓ-INSA, Associação para a Promoção da Investigação em Saúde, Instituto Nacional de Saúde Doutor Ricardo Jorg

EAIR 41st Annual Forum in Leiden, The Netherlands 25 till 28 August 2019

Trabalho apresentado em EAIR 41st Annual Forum, 25-28 agosto 2019, Leiden, Países Baixos.Polytechnic Institutes in Portugal: research on the impact of twelve institutes on the local economy Higher Education Institutions are recognized as important actors in regional development. The Portuguese higher education system comprises both Universities and Polytechnic Institutes, which face an increasing pressure to demonstrate that their presence has an impact on the surrounding communities contributing to their economic development. This paper presents the estimation of the economic impact of twelve Polytechnic Institutes, located in quite diverse regions, based on a shared model so that comparisons have a collective framework of analysis. The main results obtained show that the economic impact ranged from 1.8% to 10.6% of the local GDP and that these Institutes are major local employers.info:eu-repo/semantics/publishedVersio

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio